Synthesis, α-mannosidase inhibition studies and molecular modeling of 1,4-imino-ᴅ-lyxitols and their C-5-altered N-arylalkyl derivatives

• Martin Kalník,
• Sergej Šesták,
• Juraj Kóňa,
• Maroš Bella and
• Monika Poláková

Beilstein J. Org. Chem. 2023, 19, 282–293, doi:10.3762/bjoc.19.24

• .19.24 Abstract A synthesis of 1,4-imino-ᴅ-lyxitols and their N-arylalkyl derivatives altered at C-5 is reported. Their inhibitory activity and selectivity toward four GH38 α-mannosidases (two Golgi types: GMIIb from Drosophila melanogaster and AMAN-2 from Caenorhabditis elegans, and two lysosomal types

• model for structural and mechanistic inhibition studies [19][20][21]. On the other hand, Caenorhabditis elegans α-mannosidase II (AMAN-2) represents a Golgi-type α-mannosidase (GH38 family, E.C.3.2.1.114) and has the amino acid sequence and predicted 3D structure (based on a built homology model) of the

• -imino-ᴅ-lyxitol which configurationally better resembles swainsonine or DIM. The most promising N-substituents from the previous study were selected and a small library of N-substituted 1,4-imino-ᴅ-lyxitols was prepared [22] (Figure 1). In addition, more relevant Caenorhabditis elegans α-mannosidase II

Anthelmintic drug discovery: target identification, screening methods and the role of open science

• Frederick A. Partridge,
• Ruth Forman,
• Carole J. R. Bataille,
• Graham M. Wynne,
• Marina Nick,
• Angela J. Russell,
• Kathryn J. Else and
• David B. Sattelle

Beilstein J. Org. Chem. 2020, 16, 1203–1224, doi:10.3762/bjoc.16.105

• most promising compounds and to reduce the redundancy of effort. Such a collaborative data-sharing structure must be a priority for the field. C. elegans: a model organism for parasitology and an exemplar of an open community C. elegans as a model nematode Caenorhabditis elegans (C. elegans) is a non

Pigmentosins from Gibellula sp. as antibiofilm agents and a new glycosylated asperfuran from Cordyceps javanica

• Soleiman E. Helaly,
• Wilawan Kuephadungphan,
• Patima Phainuphong,
• Mahmoud A. A. Ibrahim,
• Kanoksri Tasanathai,
• Suchada Mongkolsamrit,
• Janet Jennifer Luangsa-ard,
• Souwalak Phongpaichit,
• Vatcharin Rukachaisirikul and
• Marc Stadler

Beilstein J. Org. Chem. 2019, 15, 2968–2981, doi:10.3762/bjoc.15.293

• against Caenorhabditis elegans was investigated using a microtiter plate assay according to Helaly and co-workers [9], while the cytotoxicity was tested against murine fibroblast (L929) and human HeLa (KB3.1) cell lines according to Chepkirui and co-workers [50]. The isolated compounds were also tested

Skeletocutins M–Q: biologically active compounds from the fruiting bodies of the basidiomycete Skeletocutis sp. collected in Africa

• Tian Cheng,
• Clara Chepkirui,
• Cony Decock,
• Josphat C. Matasyoh and
• Marc Stadler

Beilstein J. Org. Chem. 2019, 15, 2782–2789, doi:10.3762/bjoc.15.270

• isolated compounds against Caenorhabditis elegans (C. elegans) was performed in 24-well microtiter plates as previously described [11]. Ivermectin was used as positive control and methanol was used as negative control. The results are expressed as LD90 values. Inhibition of leucine aminopeptidases

Lectins of Mycobacterium tuberculosis – rarely studied proteins

• Katharina Kolbe,
• Sri Kumar Veleti,
• Norbert Reiling and
• Thisbe K. Lindhorst

Beilstein J. Org. Chem. 2019, 15, 1–15, doi:10.3762/bjoc.15.1

• mannose-specific C-type lectins from Caenorhabditis elegans, Mus musculus, and Homo sapiens (see Figure 5 for partial secondary structure prediction and alignment with the human C-type mannose receptor 2) [77][78], and is predicted to be localized to the outer membrane [93]. While Rv2075c orthologues have

Targeting the Pseudomonas quinolone signal quorum sensing system for the discovery of novel anti-infective pathoblockers

• Christian Schütz and
• Martin Empting

Beilstein J. Org. Chem. 2018, 14, 2627–2645, doi:10.3762/bjoc.14.241

• [38]. HQNO acts through inhibition of complex III in the respiratory chain of bacteria and mitochondria of eukaryotes and, hence, it can be considered a general cytotoxic agent. DHQ, a shunt product of the PQS biosynthetic pathway, is important for P. aeruginosa virulence in a Caenorhabditis elegans

Synthesis and bioactivity of analogues of the marine antibiotic tropodithietic acid

• Patrick Rabe,
• Tim A. Klapschinski,
• Nelson L. Brock,
• Christian A. Citron,
• Paul D’Alvise,
• Lone Gram and
• Jeroen S. Dickschat

Beilstein J. Org. Chem. 2014, 10, 1796–1801, doi:10.3762/bjoc.10.188

• their biosynthesis is unknown [10]. TDA exhibits a strong antibiotic activity against a broad spectrum of bacteria including alpha- and gammaproteobacteria, flavobacteria and actinobacteria [11], but not against the eukaryotic model organisms Artemia sp. and Caenorhabditis elegans, suggesting P

A practical synthesis of long-chain iso-fatty acids (iso-C₁₂–C₁₉) and related natural products

• Mark B. Richardson and
• Spencer J. Williams

Beilstein J. Org. Chem. 2013, 9, 1807–1812, doi:10.3762/bjoc.9.210

• phospholipids, they influence membrane fluidity [1]. Emerging evidence has revealed unexpected roles for certain iso-fatty acids; for example iso-C15 and iso-C17 fatty acids have been shown to be essential in the development of the model eukaryote Caenorhabditis elegans [2]. They are present as esters and

Hydrophobic analogues of rhodamine B and rhodamine 101: potent fluorescent probes of mitochondria in living C. elegans

• Laurie F. Mottram,
• Safiyyah Forbes,
• Brian D. Ackley and
• Blake R. Peterson

Beilstein J. Org. Chem. 2012, 8, 2156–2165, doi:10.3762/bjoc.8.243

• expression of mitochondria-targeted fluorescent proteins. The high bioavailabilty of these novel fluorescent probes may facilitate the identification of agents and factors that affect diverse aspects of mitochondrial biology in vivo. Keywords: Caenorhabditis elegans; chemical biology; fission; fluorophores

Volatile organic compounds produced by the phytopathogenic bacterium Xanthomonas campestris pv. vesicatoria 85-10

• Teresa Weise,
• Marco Kai,
• Anja Gummesson,
• Armin Troeger,
• Stephan von Reuß,
• Silvia Piepenborn,
• Francine Kosterka,
• Martin Sklorz,
• Ralf Zimmermann,
• Wittko Francke and
• Birgit Piechulla

Beilstein J. Org. Chem. 2012, 8, 579–596, doi:10.3762/bjoc.8.65

• volatiles of different Xanthomonas campestris species/isolates on Caenorhabditis elegans and on bacteria was also shown [20][37]. Volatile emissions of Xanthomonas campestris pv. vesicatoria 85-10 GC/MS analysis of volatiles released by X. c. pv. vesicatoria 85-10 The volatiles emitted by X. c. pv